教育和工作经历

湖大化学生物传感与计量学国家重点实验室 博士（2007）

美国能源部埃姆斯国家实验室 博士后（2008-2011）

威尼斯84881生化教研室 特聘副教授（2012）

研究简介

本课题组主要致力于新型核酸及纳米荧光探针的研究开发及其生物医学应用。发展了DNA甲基转移酶、端粒酶、蛋白激酶、磷酸酶及UDG酶等生物酶活性高灵敏检测的新方法，实现了对microRNA、c-反应蛋白、CEA、OTA等重要生物分子的高灵敏度、高特异性检测，对于疾病的早期诊断及治疗具有重要的意义。主持国家自然科学基金、威尼斯84881高层次人才引进基金、国家重点实验室开放课题等多个科研项目。在Chemical Reviews, Analytical Chemistry, Nucleic Acids Research, Microchim Acta, Talanta, Analyst, Analytical and Bioanalytical Chemistry, ChemBioChem等国际期刊发表SCI论文60篇，申请国家发明专利2项，授权专利1项，参编教材5部。2013年入选威尼斯84881“531”人才队伍建设第三层次人才。

研究方向：1、生化分析与生物传感；2、肿瘤标志物监测; 3、食品安全与分析

代表性论文（*通讯作者）:

[1] Kefeng Wu, Changbei Ma*, Zhiyi Deng, Ning Fang, Zhenwei Tang, Xingxing Zhu, Kemin Wang, Label-free and nicking enzyme-assisted fluorescence signal amplification for RNase H analysis based on a G-quadruplexe/thioflavin T complex, Talanta, 2018, 182, 142-147.

[2] Zhenwei Tang, Huifang Zhang, Changbei Ma*, Pan Gu, Gouhou Zhang, Kefeng Wu, Miangjian Chen, Kemin Wang, Colorimetric determination of the activity of alkaline phosphatase based on the use of Cu(II)-modulated G-quadruplex-based DNAzymes, Microchim Acta, 2018, 185, 109.

[3] Changbei Ma*, Kefeng Wu, Han Zhao, Haisheng Liu, Kemin Wang, Kun Xia*, Fluorometric aptasensor of ochratoxin A based on the use of graphene oxide and RNase H-aided amplification, Microchim Acta, 2018, 347.

[4] Changbei Ma*, Haisheng Liu, Kefeng Wu, Mingjian Chen, Hailun He, Kemin Wang, Kun Xia*, A turn-on fluorescence assay of alkaline phosphatase activity using a DNA-silver nanocluster probe, New Journal of Chemistry, 2018, 42, 4331-4336.

[5] Mingjian Chen, Farjana Yeasmin Khusbu, Changbei Ma*, Kefeng Wu, Han Zhao, Hanchun Chen, Kemin Wang, A sensitive detection method of carcinoembryonic antigen based on dsDNA-templated copper nanoparticles, New Journal of Chemistry, 2018, 42, 13702-13707.

[6] Xiafei Jiang, Haisheng Liu, Farjana Yeasmin Khusbu, Changbei Ma*, Anqi Ping, Qiling Zhang, Kefeng Wu, Mingjian Chen, Label-free detection of exonuclease III activity and its inhibition based on DNA hairpin probe, Analytical Biochemistry, 2018, 555, 55-58.

[7] Mingjian Chen, Zhiyi Deng, Changbei Ma*, Han Zhao, Kefeng Wu, Kemin Wang, A sensitive fluorescence method for the detection of streptavidin based on target-induced DNA machine amplification, Analytical Methods, 2018, 10, 1870-1874.

[8] Pan Gu, Gehou Zhang, Zhiyi Deng, Zhenwei Tang, Huifang Zhang, Kefeng Wu, Mingjian Chen, Changbei Ma*, A novel label-free colorimetric detection of L-histidine using Cu²⁺-modulated G-quadruplex-based DNAzymes, Spectrochimica Acta Part A, 2018, 2013, 195-200.

[9] Haisheng Liu, Changbei Ma*, Jun Wang, Kemin Wang, Kefeng Wu, A label-free turn-on fluorescence strategy for detection of alkaline phosphatase activity based on dsDNA-templated copper nanoparticles coupled with λ exonuclease, Microchim Acta, 2017, 184(7), 2483-2488.

[10] Kefeng Wu, Changbei Ma*, Haisheng Liu, Hailun He, Weimin Zeng, Kemin Wang, Label-free fluorescence assay for rapid detection of RNase H activity based on Tb3+-induced G-quadruplex conjugates, Analytical Methods, 2017, 9, 3055-3060.

[11] Haisheng Liu, Changbei Ma*, Feng Ning, Hanchun Chen, Hailun He, Kemin Wang, Jun Wang*, A facile label-free fluorescence aptasensor for rapid detection of ATP based on G-quadruplex formation, Spectrochim. Acta A., 2017, 175, 164-167.

[12] Haisheng Liu, Changbei Ma*, Jun Wang, Hanchun Chen, Kemin Wang, Label-free colorimetric assay for T4 polynucleotide kinase/phosphatase activity and its inhibitors based on G-quadruplex/hemin DNAzyme, Anal. Biochem., 2017, 517, 18-21.