【教育经历】

湖南师范大学 | 生物科学 | 学士学位 | 大学本科毕业

武汉大学 | 微生物学 | 博士学位 | 博士研究生毕业

【工作经历】

2007.5-2009.9  细胞生物学系 | 威尼斯84881  讲师

2009.9-2014.9  细胞生物学系 | 威尼斯84881 | 副教授

2014.9-至今  细胞生物学系 | 威尼斯84881 | 教授

【行政职务】

威尼斯84881副院长

【研究综述】

主要从事人类疾病致病或易感基因的鉴定及其相关细胞和基因功能研究。

近年，主持和参与包括国家自然科学基金面上项目、国家科技重大专项子课题、863子课题、军口项目子课题、省自然科学基金等在内的各级科研项目20余项；在Circulation、J Neurosci、Eur Heart J、Apoptosis等杂志上发表论文30余篇；参与申请发明专利10余项，已授权4项。主编教材1部，参编国家级规划教材2部；参与教改课题4项；指导国家级、省级大学生创新课题3项，指导大学生国家级竞赛一等奖2项、三等奖2项、省级竞赛一等奖、二等奖等；连续获校教学质量优秀奖3次、校级教学成果一等奖1次、教学“三十佳”1次等，被评为威尼斯84881学科竞赛优秀指导教师、创客空间优秀指导老师，湖南省“挑战杯”优秀指导老师、长沙市大学生科创大赛优秀指导教师等。

【研究方向】

课题组目前主要开展2个方面的研究：

（1）运用新一代测序、色谱、细胞免疫等技术，从基因、分子、细胞、模式动物及人体水平探讨动脉粥样硬化、高血脂、心肌病等心血管相关疾病的发病机理，并结合临床筛选相关疾病的早期检测诊断分子和预后标志物；

（2）研究病原微生物感染、肿瘤、原发性多囊肾等疾病发生过程中相关细胞器、细胞信号转导、细胞物质运输、细胞代谢等细胞结构和功能的异常。

【代表论文】

[1] Xiang R^#,*（通讯作者，第一作者）, Fan L L^#, Huang H^#, Chen Y Q^#, He W X, Guo S, Li J J, Jin J Y, Du R, Yan R Q, Xia K. Increased RTN3 Leads to Obesity and Hypertriglyceridemia by Interacting with HSPA5[J]. Circulation, 2018, online.

[2] Guo S, Fan X F, Jin J Y, Fan L L, Zhou Z B, Xiang R^*（共同通讯作者）, Tang J Y^*. A novel proximal 3q29 chromosome microdeletion in a Chinese patient with Chiari malformation type II and Sprengel’s deformity[J]. Molecular cytogenetics, 2018, 11(1): 8.

[4] Ding D B, Fan L L, Xiao Z, Huang H, Chen Y Q, Guo S, Liu Z H, Xiang R^*（通讯作者）. A novel mutation of dipeptidyl aminopeptidase-like protein-6 in a family with suspicious idiopathic ventricular fibrillation[J]. QJM: An International Journal of Medicine, 2018, 111(6): 373-377.

[5] Huang H, Ding D B, Fan L L, Jin J Y, Li J J, Guo S, Chen Y Q, Xiang R^*（通讯作者）. Whole-exome sequencing identifies a Novel SCN5A mutation (C335R) in a Chinese family with arrhythmia[J]. Cardiology in the young, 2018, 28(5): 688-691.

[6] Li J J, Chen Y Q, Fan L L, Jin J Y, Guo S, Xiang R^*（通讯作者）. Microduplication of 10q26. 3 in a Chinese hypertriglyceridemia patient[J]. Molecular and cellular probes, 2018, 37: 28-31.

[7] Fan L L, Huang H, Jin J Y, Li J J, Chen Y Q, Zhao S P, Xiang R^*（通讯作者）. Whole exome sequencing identifies a novel mutation (c. 333+ 2T> C) of TNNI3K in a Chinese family with dilated cardiomyopathy and cardiac conduction disease[J]. Gene, 2018, 648: 63-67.

[8] Huang H, Chen Y Q, Fan L L, Guo S, Li J J, Jin J Y, Xiang R^*（通讯作者）. Whole-exome sequencing identifies a novel mutation of GPD1L (R189X) associated with familial conduction disease and sudden death[J]. Journal of cellular and molecular medicine, 2018, 22(2): 1350-1354.

[9] Xiang R^*（第一作者，共同通讯作者）, Fan L L, Lin M J, Li J J, Shi X Y, Jin J Y, Liu Y X, Chen Y Q, Xia K^*, Zhao S P^*.The genetic spectrum of familial hypercholesterolemia in the central south region of China[J]. Atherosclerosis, 2017, 258: 84-88.

[10] Liu J S, Fan L L, Li J J, Xiang R^*（通讯作者）. Whole-exome sequencing identifies a novel mutation of desmocollin 2 in a Chinese family with arrhythmogenic right ventricular cardiomyopathy[J]. The American journal of cardiology, 2017, 119(9): 1485-1489.

[11] Liu J S, Fan L L, Zhang H, Liu X, Huang H, Tao L J, Xia K, Xiang R^*（通讯作者）. Whole-exome sequencing identifies two novel TTN mutations in Chinese families with dilated cardiomyopathy[J]. Cardiology, 2017, 136(1): 10-14.

[12] Xiang R^*（第一作者，通讯作者）, Du R, Guo S, Jin J Y, Fan L L, Tang J Y, Zhou Z B. Microduplications of 10q24 Detected in Two Chinese Patients with Split-hand/foot Malformation Type 3[J]. Annals of Clinical & Laboratory Science, 2017, 47(6): 754-757.

[13] Xiang R（第一作者）, Fan L L, Huang H, Zhao S P, Chen Y Q. Whole-exome sequencing identifies a novel mutation of DSG2 (Y198C) in a Chinese arrhythmogenic right ventricular cardiomyopathy patient[J]. International journal of cardiology, 2016, 214: 1-3.

[14] Wu P F, Guo S, Fan X F, Fan L L, Jin J Y, Tang J Y, Xiang R^*（通讯作者）. A novel ZRS mutation in a Chinese patient with Preaxial Polydactyly and Triphalangeal thumb[J]. Cytogenetic and genome research, 2016, 149(3): 171-175.

[15] Du RF, Huang H, Fan L L, Li X P, Xia K^*, Xiang R^*（共同通讯作者）. A Novel Mutation of FOXC1 (R127L) in an Axenfeld–Rieger Syndrome Family with Glaucoma and Multiple Congenital Heart Diseases[J]. Ophthalmic genetics, 2016, 37(1): 111-115.

[16] Chen Y, Wu Z, Zhao S, Xiang R. Chemical chaperones reduce ER stress and adipose tissue inflammation in high fat diet-induced mouse model of obesity[J]. Scientific reports, 2016, 6: 27486.

[17] Fan L L, Lin M J, Chen Y Q, Huang H, Peng D Q, Xia K^*, Zhao S P^*, Xiang R^*（共同通讯作者）. Novel mutations of low-density lipoprotein receptor gene in China patients with familial hypercholesterolemia[J]. Applied biochemistry and biotechnology, 2015, 176(1): 101-109.

[18] Yu B L, Xiang R, Hu D, Peng D Q. A novel MYH7 mutation in a family with cardiomyopathy presenting with restrictive physiology and varying degrees of left ventricle hypertrophy[J]. European heart journal, 2014, 36(3): 178-178.

[19] Shi Q, Ge Y, Sharoar M G, He W, Xiang R, Zhang Z, Hu X, Yan R. Impact of RTN3 deficiency on expression of BACE1 and amyloid deposition[J]. Journal of Neuroscience, 2014, 34(42): 13954-13962.

[20] Xiang R（第一作者）, Fan L L, Huang H, Cao B B, Li X P, Peng D Q^*, Xia K^*. A novel mutation of GATA4 (K319E) is responsible for familial atrial septal defect and pulmonary valve stenosis[J]. Gene, 2014, 534(2): 320-323.

[21] Chen Y, Xiang R, Zhao S. The potential role of RTN3 in monocyte recruitment and atherosclerosis[J]. Molecular and cellular biochemistry, 2012, 361(1-2): 67-70.

[22] Chen Y, Zhao S, Xiang R^*（通讯作者）. RTN3 and RTN4: candidate modulators in vascular cell apoptosis and atherosclerosis[J]. Journal of cellular biochemistry, 2010, 111(4): 797-800.

[23] Xing Y, Zhao S, Xiang R^*（通讯作者）. Alzheimer’s disease and atherosclerosis: Passers-by or brothers?[J]. Medical hypotheses, 2009, 73(2): 138-139.

[24] Xiang R, Zhao S. RTN3 inducing apoptosis is modulated by an adhesion protein CRELD1[J]. Molecular and cellular biochemistry, 2009, 331(1-2): 225.

[25] Zhu L, Xiang R（并列）, Dong W, et al. Anti‐apoptotic activity of Bcl‐2 is enhanced by its interaction with RTN3[J].Cell biology international, 2007, 31(8): 825-830.

[26] Xiang R, Liu Y, Zhu L, et al. Adaptor FADD is recruited by RTN3/HAP in ER-bound signaling complexes[J]. Apoptosis, 2006, 11(11): 1923-1932.

[27] Liu Y, Dong W, Chen L, Xiang R, Xiao H, De G, Wang Z, Qi Y. BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2[J]. Journal of Biological Chemistry, 2004, 279(36): 37436-37444.