教育经历

2012/09–2018/01，中国科学院遗传与发育生物学研究所，博士

2009/9–2012/6，湖南农业大学，药用植物资源工程系，硕士

2005/9–2009/6，湖南农业大学，药用植物资源工程系，学士

研究方向

自闭症谱系障碍(Autism spectrum disorder)是一种常见的神经发育障碍疾病，患者的典型特征有社交异常，语言障碍以及刻板重复行为和兴趣狭窄。由于自闭症的高度临床和病因异质性，到目前为止，其发病机制仍不清楚，尚无治疗自闭症的有效方法。我们将围绕自闭症发病机制及防治这一核心问题，充分利用团队在基因改造小鼠模型及神经发育研究方面的优势，从基因功能、神经元活性和整体行为等不同层面，综合运用多学科研究方法和先进技术，系统研究自闭症的发病机制。

1.根据遗传学研究结果，筛选自闭症候选致病基因，构建基因敲除或点突变小鼠模型，并研究其在神经发育过程中的生理功能。

2.对基因敲除或点突变小鼠模型进行神经电生理特性分析及神经环路机制研究。

3.从分子、细胞水平研究基因敲除或点突变导致小鼠自闭症样表型的致病机制。

代表性论文（^#共同一作，^*共同通讯）

(1) Ling Yuan ^(#), Xingyao Huang ^(#), Zhongyu Liu ^(#), Feng Zhang ^(#), Xingliang Zhu^(#),Jiuyang Yu^(#), Xue Ji, Yanpeng Xu, Guanghui Li, Cui Li, Hongjiang Wang, Yongqiang Deng, Menghua Wu, Mengli Cheng, Qing Ye, Dongyang Xie, Xiaofeng Li, Xiangxi Wang, Weifeng Shi, Baoyang Hu, Peiyong Shi, Zhiheng Xu^(*), Chengfeng Qin^(*), A single mutation in the prM protein of Zika virus contributes to fetal microcephaly , Science, 2017, 358(6365): 933-936

(2) Feng Zhang^(#), Hongjiang Wang^(#), Qin Wang^(#), Zhongyu Liu^(#), Ling Yuan^(#), Xingyao Huang^(#), Guanghui Li, Qing Ye, Haozhen Yang, Lei Shi, Yongqiang Deng, Chengfeng Qin^(*), Zhiheng Xu^(*), American Strain of Zika Virus Causes More Severe Microcephaly Than an Old Asian Strain in Neonatal Mice, EBioMedicine, 2017, 25: 95~105

(3) Ling Yuan ^(#), Ligui Xiong^(#), Tingting Deng, Yang Wu, Juan Li, Shuoqian Liu, Jianan Huang, Zhonghua Liu^(*), Comparative profiling of gene expression in Camellia sinensis L. cultivar AnJiBaiCha leaves during periodic albinism , Gene, 2015, 561(1): 23~29

(4) Chunfeng Li^(#), Xingliang Zhu^(#), Xue Ji^(#), Natalie Quanquin, Yongqiang Deng; Min Tian, Roghiyh Aliyari, Xiangyang Zuo, Ling Yuan, Shabbir Khan Afridi, Xiaofeng Li, Jae U. Jung, Nielsen-Saines Karin, Frank Xiaofeng Qin^(*), Chengfeng Qin^(*), Zhiheng Xu^(*), Genhong Cheng^(*), Chloroquine, a FDA-approved Drug, Prevents Zika Virus Infection and its Associated Congenital Microcephaly in Mice , EBioMedicine, 2017, 24: 189~194

(5) Ki-Jun Yoon^(#), Guang Song, Xuyu Qian, Jianbo Pan, Dan Xu, Hee-Sool Rho, Nam-Shik Kim, Christa Habela, Lily Zheng, Fadi Jacob, Feiran Zhang, Emily M. Lee, Weikai Huang, Francisca Rojas Ringeling, Caroline Vissers, Cui Li, Ling Yuan, Koeun Kang, Sunghan Kim, Junghoon Yeo, Yichen Cheng, Sheng Liu, Zhexing Wen, Chengfeng Qin, Qingfeng Wu, Kimberly M. Christian, Hengli Tang, Peng Jin, Zhiheng Xu, Jiang Qian, Heng Zhu, Hongjun Song, Guoli Ming^(*), Zika-Virus-Encoded NS2A Disrupts Mammalian Cortical Neurogenesis by Degrading Adherens Junction Proteins , Cell Stem Cell, 2017, 21(3): 349-358

(6) Feng Zhang^(#), Dan Xu, Ling Yuan, Yiming Sun, Zhiheng Xu^(*), Epigenetic regulation of Atrophin1 by lysine-specific demethylase 1 is required for cortical progenitor maintenance , Nature Communications, 2014, 5: 5815